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KMID : 1094020080250060494
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Journal of Veterinary Clinics
2008 Volume.25 No. 6 p.494 ~ p.500
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The Effects of Hyaluronic Acid-Carboxymethylcellulose Membrane (GUARDIX-MB(R)) Barriers on Prevention of Post-operation Peritoneal Adhesions in Dogs
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Lee Sang-Mook
Jang Hwan-Soo
Bae Jae-Sung
Kim Jung-Eun
Jang Kwang-Ho
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Abstract
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The aim of this study was to determine the effectiveness of hyaluronic acid-carboxymethylcellulose membrane (GUARDIX-MB®) barriers on prevention against post-operative peritoneal adhesions. In this study, fourteen mongrel dogs were divided into two experimental groups: 0.1 % hyaluronic acid (0.1HA) group and hyaluronic-acidcarboxymethylcellulose membrane (HA-CMC) group. In order to induce adhesions, the anti-mesenteric serosa of the ileum was exteriorized and then abraded in a standard manner by scraping with a scalpel blade to create homogenous petechial hemorrhagic surface over a 1 × 1 cm area. Solution of 0.1HA were simply coated over the abraded tissues, 1.5 × 1.5 cm HA-CMC membrane was placed over the abraded tissues, allowed to spread across the intra-abdominal organs before closure of the abdomen. On day 1 before and day 1, 4, 7, 14, and 21 after operation, venous blood specimens were collected for measurement of fibrinogen and total WBC. The adhesions were blindly assessed 3 weeks later by using a computerized tensiometer. The fibrinogen and total WBC values of two groups showed no statistical significances. The mean tensile strength (gram force, gf) of formed adhesions day 21 after surgery was 88.1 ± 55.70 gf in the 0.1 % HA group and 24.8 ± 22.69 gf in the HA-CMC group. The tensile strength values of adhesion separation HA-CMC membrane group was significantly lower than the 0.1HA group (p<0.05). Therefore, we suggest that HACMC membrane reduce peritoneal adhesions may be applicable to preventing post-operative intraperitoneal adhesions
in dogs.
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KEYWORD
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hyaluronic acid-carboxymethylcellulose membrane , peritoneal adhesions , tensile strength , dogs
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